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best glp 1 for perimenopause The GLP-1/GIP dual-receptor agonist tirzepatide led to at least 15% loss of total body fat in premenopausal, perimenopausal, and postmenopausal women, but postmenopausal women taking menopausal hormone therapy had the greatest weight

Marsoni M251S
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Mariel
Louisville, US
★★★★★ 5
Well made, light fabric. Waist doesn't roll.
These bamboo underwear really do keep you cool. They fit true to size, and wear easily. the wide elastic waist band doesn't roll on me. They are comfortable to wear, washed and dried easily. The material has some stretch to it, but not a lot. Well made, no stray strings. Perfect fit for me. Just what I was looking for.
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Reviewed in the United States on May 17, 2026
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Finngirl
Charlottesville, US
★★★★★ 5
Good quality, smooth feel
I got these briefs so recently that have washed just one pair so far. First off, these are very comfortable, the material is soft & bordering silky, good quality sewing. Wash well and minimal if any shrinkage. They do come a bit wrinkled from the dryer but hey, these are underwear and will go on smoothly. If it were a t-shirt, I would look sloppy. I feel the sizing is accurate. No rolling and these don't announce themselves under clothing. Planning on getting more of these boxers and replacing my old panties.
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Reviewed in the United States on January 31, 2026
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Skurtzo
Belleville, US
★★★★★ 4
A little snug on the thighs
Size: Medium, Color: Multicoloured G (5-pack)
Super comfy, soft and thin. For reference, I'm 5'6", 135, athletic build. I bought medium. I almost returned them because I thought they were a bit too snug on my thighs, and my thighs are not large at all. I was concerned about panty lines under snug clothing. But, because they're thin, I figured they would probably stretch, so I kept them. So far, I've only worn them under a night shirt, but they're super comfortable and they dont ride up at all. Very nice, but if your thighs are a little thick, you probably won't like them.
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Reviewed in the United States on August 29, 2025
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Shanna
Cuba, US
★★★★★ 5
Functional + Sexy
Size: Small, Color: Multicoloured E-(5-pack), Size: Small, Color: Multicoloured E-(5-pack)
Not only do these feel good, my husband can’t keep his hands off me. They fit so good and are soft. I change into these to sleep but also just use them as shorts to wear around the house. They’re comfortable and don’t slide around. I got a size small and I’m 100lbs.
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Reviewed in the United States on April 13, 2026
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ClairY
Carnegie, US
★★★★★ 5
Finally!
Size: X-Large, Color: All Black D (5-pack)
Finally, comfortable underwear that don’t end up giving me a wedgie. I have a round booty and most cuts of underwear end up shifting as I walk and sit. The hem of the underwear comes right under my cheeks and the lightweight material ensures there’s no panty line and no shifting to where I don’t want them! I’m definitely purchasing more.
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Reviewed in the United States on May 17, 2026

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